Last edited by Arakree
Monday, May 11, 2020 | History

3 edition of Insulin-like Growth Factors and Cancer found in the catalog.

Insulin-like Growth Factors and Cancer

From Basic Biology to Therapeutics

by Derek LeRoith

  • 393 Want to read
  • 33 Currently reading

Published by Springer Science+Business Media, LLC in Boston, MA .
Written in English

    Subjects:
  • Medicine,
  • Toxicology,
  • Oncology

  • Edition Notes

    Statementedited by Derek LeRoith
    SeriesCancer Drug Discovery and Development
    ContributionsSpringerLink (Online service)
    The Physical Object
    Format[electronic resource] :
    ID Numbers
    Open LibraryOL25553305M
    ISBN 109781461405979, 9781461405986

    BACKGROUND AIMS: Human studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 3 (IGFBP3) and colorectal cancer . Insulin-like growth factor is a type of growth factor and a type of cytokine. Also called IGF and somatomedin. National Cancer Institute at the National Institutes of Health.

    Insulin-like Growth Factors and Cancer by Derek LeRoith; 2 editions; First published in ; Subjects: Medicine, Toxicology, Oncology.   Insulin-like growth factor (IGF) can affect your blood glucose levels. IGF may be used as a treatment for diabetes, but more research is necessary. Subscribe. and cancer : Ann Pietrangelo.

      Research into a hormone called insulin-like growth factor 1 may be the key to understanding cancer growth — and how to stop it. Studies indicate that higher levels of the hormone promote tumor development, and lowering IGF-1 levels can help the body increase its natural cancer . Insulin-like growth factors (IGFs) are essential for growth and survival that suppress apoptosis and promote cell cycle progression, angiogenesis, and metastatic activities in various cancers. The IGFs Cited by:


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Insulin-like Growth Factors and Cancer by Derek LeRoith Download PDF EPUB FB2

Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, specifically brings these aspects to the reader. The volume covers the epidemiological aspects of the relationships between circulating insulin and IGF-1 levels and the risk for cancer and cancer-related mortality and in particularly in disease states such as obesity and Type 2 : Hardcover.

Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, specifically brings these aspects to the reader. The volume covers the epidemiological aspects of the relationships between circulating insulin and IGF-1 levels and the risk for cancer and cancer-related mortality and in particularly in disease states such as obesity and Type 2 diabetes.

The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer. Insulin-like Growth Factors and Cancer - From Basic Biology to. Population, preclinical, and basic data suggest the insulin-like growth factor (IGF) system functions to maintain the malignant phenotype in breast cancer.

Since the IGFs act via transmembrane tyrosine kinase receptors, targeting of the key receptors could provide a new pathway in breast by: Read "Insulin-like Growth Factors and Cancer From Basic Biology to Therapeutics" by available from Rakuten Kobo.

The book will detail the history, successes, and failures of targeted therapies for cancer Brand: Springer US. Insulin-like growth factors and cancer: from basic biology to therapeutics. [Derek LeRoith;] -- AnnotationThis book explores the insulin-like growth factor system and its vital role in cancer development.

Lancet Oncol. May;3(5) Insulin-like growth factors and cancer. Fürstenberger G(1), Senn HJ. Author information: (1)Center for Tumour Detection and Prevention, St Gallen, Switzerland.

[email protected] Interest in insulin-like growth factors Cited by: Summary Interest in insulin-like growth factors (IGFs) and their effect on carcinogenesis has increased recently because high serum concentrations of IGF1 are associated with an increased risk of breast, prostate, colorectal, and lung by:   insulin, insulin-like growth factors, colon cancer, adenomas The strong relationship between Westernization and colon cancer incidence has spawned a number of explanatory hypotheses, many focused on the influence of dietary fat Cited by: springer, The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer.

springer Insulin-like Growth Factors and Cancer. Insulin-like growth factors (IGFs) have potent mitogenic and antiapoptotic effects on prostate epithelial cells. Through modulation of IGF bioactivity and other mechanisms, IGF-binding proteins Cited by: This book explores the insulin-like growth factor system and its vital role in cancer development and progression.

Covers biology, epidemiology and the therapeutic potential of inhibiting receptors Read. The Insulin-like Growth Factor 1 (IGF-1) signaling pathway activates several downstream signals important to cancer development and survival.

Once insulin is bound to these receptors it activates. Medical Books Free. Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics Oncology.

Oct 08 The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer.

The insulin-like growth factors, IGF1 and IGF2, are an increasingly important focus for breast cancer research. Expressed in most organs, IGF1 and IGF2 are circulating peptide hormones and locally acting growth factors Cited by: 7. The growth factor, known as insulin-like growth factor-1, or IGF-1, is necessary for proper growth in children, but studies of men and women more than 40 years old raise the possibility that it contributes to the growth Author: William J.

Cromie. Insulin-like growth factor pathway genes and blood concentrations, dietary protein and risk of prostate cancer in the NCI Breast and Prostate Cancer Cohort Consortium (BPC3).

International Journal of Cancer Cited by: Similar Items. Insulin-like growth factors: molecular and cellular aspects / Published: () The growth hormone/insulin-like growth factor axis during development Published: () ; Insulin resistance and cancer. fig The insulin-like growth factor 1 receptor (IGF-1R), a transmembrane receptor tyrosine kinase, is activated by its cognate ligands, insulin-like growth factor-1 (IGF-1) and -2 (IGF-2), resulting in receptor auto-transphosphorylation and signaling cascades that progress through the IRS-l/PI3K/AKT and MAPK pathways.

Stimulation of both pathways ultimately leads to various cancer. Insulin-like growth factor-I acts as an important mediator between growth hormone and growth throughout fetal and childhood development. Its effects and those of the other insulin-like growth factors are modulated by at least six different binding proteins.

The role of insulin-like growth factor-I in promoting cancer Cited by:. Authors who wish to cite a section of the conference and specifically indicate its author may use this example for the form of reference: Baserga R.

The role of insulin-like growth factor 1 receptor in cell growth and transformation, pp In: LeRoith D, moderator.

Insulin-like growth factors and cancer Cited by: The Insulin-Like Growth Factor I Receptor: Molecular Biology, Heterogeneity and Regulation. Biological Actions of the Insulin-Like Growth Factors. Insulin-Like Growth Factor II: Gene Structure and Expression into Messenger RNA and Protein.

The Insulin-Like Growth Factor-II/Mannose 6-Phosphate Receptor. Insulin-Like Growth Factor .Insulin-like growth factor 1 (IGF-1, or sometimes with a Roman numeral as IGF-I) is mainly secreted by the liver as a result of stimulation by growth hormone (GH).

IGF-1 is important for both the regulation .